Drug interactions
Ledipasvir / sofosbuvir + Omeprazole
Severity: Moderate
Ledipasvir / sofosbuvir and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir is less soluble at higher pH, so acid suppression can lower its absorption and potentially reduce hepatitis C cure rates. Effects are limited at lower omeprazole doses given with the antiviral.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Omeprazole raises gastric pH, reducing ledipasvir solubility and absorption.
What to do
Take omeprazole at a dose of 20 mg or less simultaneously with ledipasvir/sofosbuvir under fasting conditions. Avoid higher PPI doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Omeprazole?
MediHelp rates the interaction as moderate. Ledipasvir / sofosbuvir and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir is less soluble at higher pH, so acid suppression can lower its absorption and potentially reduce hepatitis C cure rates. Effects are limited at lower omeprazole doses given with the antiviral.
How serious is the interaction between Ledipasvir / sofosbuvir and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take omeprazole at a dose of 20 mg or less simultaneously with ledipasvir/sofosbuvir under fasting conditions. Avoid higher PPI doses.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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