Drug interactions
Ledipasvir-sofosbuvir + Regorafenib
Severity: Moderate
Ledipasvir-sofosbuvir and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib may inhibit BCRP and increase exposure to BCRP substrates such as ledipasvir and sofosbuvir. The clinical effect is uncertain but could increase adverse effects.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Regorafenib belongs to Oncology.
Why it happens
Regorafenib is predicted to inhibit BCRP-mediated efflux.
What to do
Monitor for adverse effects of the antiviral combination and regorafenib toxicity such as hepatotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Regorafenib
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Regorafenib?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib may inhibit BCRP and increase exposure to BCRP substrates such as ledipasvir and sofosbuvir. The clinical effect is uncertain but could increase adverse effects.
How serious is the interaction between Ledipasvir-sofosbuvir and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the antiviral combination and regorafenib toxicity such as hepatotoxicity.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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