Drug interactions
Ledipasvir / sofosbuvir + Rimegepant
Severity: Moderate
Ledipasvir / sofosbuvir and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir inhibits intestinal P-glycoprotein and may increase rimegepant absorption. The increase is probably modest.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux of rimegepant.
What to do
Avoid a second rimegepant dose within 48 hours and monitor tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Rimegepant?
MediHelp rates the interaction as moderate. Ledipasvir / sofosbuvir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir inhibits intestinal P-glycoprotein and may increase rimegepant absorption. The increase is probably modest.
How serious is the interaction between Ledipasvir / sofosbuvir and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours and monitor tolerability.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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