Drug interactions
Ledipasvir / sofosbuvir + Rosuvastatin
Severity: Major
Ledipasvir / sofosbuvir and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir increases rosuvastatin exposure substantially, raising the risk of myopathy including rhabdomyolysis.
What this interaction means in plain words
Ledipasvir / sofosbuvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ledipasvir inhibits intestinal BCRP and hepatic OATP1B transporters, increasing rosuvastatin absorption and reducing clearance.
What to do
Use the lowest effective rosuvastatin dose or temporarily withhold it during treatment, and monitor for muscle symptoms and CK.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Ledipasvir / sofosbuvir with Rosuvastatin?
MediHelp rates the interaction as major. Ledipasvir / sofosbuvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ledipasvir increases rosuvastatin exposure substantially, raising the risk of myopathy including rhabdomyolysis.
How serious is the interaction between Ledipasvir / sofosbuvir and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose or temporarily withhold it during treatment, and monitor for muscle symptoms and CK.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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