Drug interactions
Ledipasvir-sofosbuvir + Venetoclax
Severity: Moderate
Ledipasvir-sofosbuvir and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir inhibits P-gp, which can increase venetoclax absorption and exposure. Higher venetoclax levels raise the risk of neutropenia and tumor lysis syndrome.
What this interaction means in plain words
Ledipasvir-sofosbuvir and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ledipasvir-sofosbuvir belongs to Anti Virals; Venetoclax belongs to Miscellaneous.
Why it happens
Ledipasvir inhibits intestinal P-gp efflux of venetoclax, increasing its bioavailability.
What to do
Monitor blood counts and tumor lysis risk closely. Reduce the venetoclax dose by at least 50% per labeling when a P-gp inhibitor is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Ledipasvir-sofosbuvir with Venetoclax?
MediHelp rates the interaction as moderate. Ledipasvir-sofosbuvir and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir inhibits P-gp, which can increase venetoclax absorption and exposure. Higher venetoclax levels raise the risk of neutropenia and tumor lysis syndrome.
How serious is the interaction between Ledipasvir-sofosbuvir and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tumor lysis risk closely. Reduce the venetoclax dose by at least 50% per labeling when a P-gp inhibitor is required.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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