Drug interactions
Lefamulin + Oxytocin
Severity: Moderate
Lefamulin and Oxytocin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin prolongs the QT interval and oxytocin may do so as well, so combined use may increase arrhythmia risk. The concern is greater with hypokalemia, bradycardia or underlying heart disease.
What this interaction means in plain words
Lefamulin and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Oxytocin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider an alternative antibiotic if the patient has other QT risk factors; otherwise check ECG and electrolytes and monitor cardiac rhythm during co-administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxytocin
- Carboprost tromethamine + Oxytocin Major
- Dinoprostone + Oxytocin Major
- Ephedrine + Oxytocin Major
- Fexinidazole + Oxytocin Major
- Givinostat + Oxytocin Major
- Misoprostol + Oxytocin Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Oxytocin?
MediHelp rates the interaction as moderate. Lefamulin and Oxytocin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin prolongs the QT interval and oxytocin may do so as well, so combined use may increase arrhythmia risk. The concern is greater with hypokalemia, bradycardia or underlying heart disease.
How serious is the interaction between Lefamulin and Oxytocin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic if the patient has other QT risk factors; otherwise check ECG and electrolytes and monitor cardiac rhythm during co-administration.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Dinoprostone, Ephedrine. The full list is on the Oxytocin page.
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