Drug interactions
Lefamulin + Quetiapine
Severity: Major
Lefamulin and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a moderate CYP3A4 inhibitor and increases exposure to CYP3A substrates. Quetiapine is mainly cleared by CYP3A4 and can prolong the QT interval, and lefamulin itself prolongs QT, so the combination may add to arrhythmia risk. Lefamulin labeling advises against use of the oral form with QT-prolonging CYP3A substrates.
What this interaction means in plain words
Lefamulin and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 raises quetiapine levels, combined with additive QT prolongation.
What to do
Avoid concurrent use where possible and choose an alternative antibiotic; if unavoidable, monitor ECG and electrolytes and consider reducing the quetiapine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Quetiapine?
MediHelp rates the interaction as major. Lefamulin and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin is a moderate CYP3A4 inhibitor and increases exposure to CYP3A substrates. Quetiapine is mainly cleared by CYP3A4 and can prolong the QT interval, and lefamulin itself prolongs QT, so the combination may add to arrhythmia risk. Lefamulin labeling advises against use of the oral form with QT-prolonging CYP3A substrates.
How serious is the interaction between Lefamulin and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose an alternative antibiotic; if unavoidable, monitor ECG and electrolytes and consider reducing the quetiapine dose.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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