Drug interactions
Lefamulin + Umeclidinium-vilanterol
Severity: Moderate
Lefamulin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin is a CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates such as vilanterol. It also prolongs the QT interval, and increased beta-agonist exposure could add to cardiovascular effects like tachycardia and hypokalemia. The label contraindicates oral lefamulin with CYP3A substrates that prolong QT, but vilanterol is not a recognized QT-prolonging drug at inhaled doses.
What this interaction means in plain words
Lefamulin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lefamulin belongs to Anti Bacterial; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 by lefamulin may increase systemic vilanterol exposure, with possible additive QT and adrenergic effects.
What to do
Monitor heart rate, ECG and potassium, particularly with oral lefamulin or other QT-prolonging drugs. Correct hypokalemia and watch for beta-agonist adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lefamulin and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Lefamulin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin is a CYP3A4 inhibitor and can raise exposure to CYP3A4 substrates such as vilanterol. It also prolongs the QT interval, and increased beta-agonist exposure could add to cardiovascular effects like tachycardia and hypokalemia. The label contraindicates oral lefamulin with CYP3A substrates that prolong QT, but vilanterol is not a recognized QT-prolonging drug at inhaled doses.
How serious is the interaction between Lefamulin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, particularly with oral lefamulin or other QT-prolonging drugs. Correct hypokalemia and watch for beta-agonist adverse effects.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
