Drug interactions
Lefamulin + Vardenafil
Severity: Major
Lefamulin and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin, particularly the oral form, inhibits CYP3A4 and may increase vardenafil levels. Both drugs can prolong the QT interval, so the combination raises the risk of arrhythmia including torsades de pointes.
What this interaction means in plain words
Lefamulin and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lefamulin belongs to Anti Bacterial; Vardenafil belongs to Genitourinary.
Why it happens
CYP3A4 inhibition by lefamulin raises vardenafil exposure, with additive QT prolongation.
What to do
Avoid the combination where possible, especially with oral lefamulin. If both are essential, use a low vardenafil dose and consider ECG monitoring and correction of potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Lefamulin with Vardenafil?
MediHelp rates the interaction as major. Lefamulin and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin, particularly the oral form, inhibits CYP3A4 and may increase vardenafil levels. Both drugs can prolong the QT interval, so the combination raises the risk of arrhythmia including torsades de pointes.
How serious is the interaction between Lefamulin and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially with oral lefamulin. If both are essential, use a low vardenafil dose and consider ECG monitoring and correction of potassium and magnesium.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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