Drug interactions
Lemborexant + Methadone
Severity: Moderate
Lemborexant and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone adds sedative effects to lemborexant and may modestly increase its exposure, worsening next-day drowsiness and psychomotor impairment.
What this interaction means in plain words
Lemborexant and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression plus possible weak CYP3A4 inhibition by methadone raising lemborexant levels.
What to do
Use the lowest effective lemborexant dose and monitor for excessive sedation and respiratory depression. Counsel patients on impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lemborexant and Methadone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Methadone?
MediHelp rates the interaction as moderate. Lemborexant and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methadone adds sedative effects to lemborexant and may modestly increase its exposure, worsening next-day drowsiness and psychomotor impairment.
How serious is the interaction between Lemborexant and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and monitor for excessive sedation and respiratory depression. Counsel patients on impaired driving.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
