Drug interactions
Lemborexant + Morphine
Severity: Moderate
Lemborexant and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause CNS depression, so combined use can increase somnolence and impair next-day alertness and coordination. Falls and driving impairment are the key risks.
What this interaction means in plain words
Lemborexant and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and orexin receptor antagonism.
What to do
Use the lowest effective doses and warn patients about impaired alertness and driving. Reduce the lemborexant dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Morphine?
MediHelp rates the interaction as moderate. Lemborexant and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause CNS depression, so combined use can increase somnolence and impair next-day alertness and coordination. Falls and driving impairment are the key risks.
How serious is the interaction between Lemborexant and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn patients about impaired alertness and driving. Reduce the lemborexant dose if excessive sedation occurs.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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