Drug interactions
Lemborexant + Nifedipine
Severity: Moderate
Lemborexant and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 inhibitor and may raise lemborexant exposure. Higher lemborexant levels can increase next-day somnolence and impaired alertness or driving ability.
What this interaction means in plain words
Lemborexant and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4-mediated lemborexant metabolism increases its plasma concentrations.
What to do
Limit lemborexant to the reduced maximum nightly dose recommended in labeling for weak CYP3A4 inhibitors. Monitor for daytime sedation and counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Nifedipine?
MediHelp rates the interaction as moderate. Lemborexant and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine is a weak CYP3A4 inhibitor and may raise lemborexant exposure. Higher lemborexant levels can increase next-day somnolence and impaired alertness or driving ability.
How serious is the interaction between Lemborexant and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum nightly dose recommended in labeling for weak CYP3A4 inhibitors. Monitor for daytime sedation and counsel patients about driving.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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