Drug interactions
Lemborexant + Nilotinib
Severity: Moderate
Lemborexant and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase lemborexant exposure. This can increase next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Lemborexant and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4, the main metabolic pathway of lemborexant.
What to do
Limit lemborexant to the lower recommended dose when given with weak CYP3A4 inhibitors. Monitor for daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Nilotinib?
MediHelp rates the interaction as moderate. Lemborexant and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase lemborexant exposure. This can increase next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Lemborexant and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower recommended dose when given with weak CYP3A4 inhibitors. Monitor for daytime drowsiness.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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