Drug interactions
Lemborexant + Oxazepam
Severity: Moderate
Lemborexant and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with an orexin antagonist increases sedation and may worsen next-day drowsiness and psychomotor impairment. Falls and driving accidents are the main concerns.
What this interaction means in plain words
Lemborexant and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and orexin receptor blockade.
What to do
Avoid combined use where possible; if necessary, use the lowest doses and consider reducing lemborexant. Counsel about next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Oxazepam?
MediHelp rates the interaction as moderate. Lemborexant and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a benzodiazepine with an orexin antagonist increases sedation and may worsen next-day drowsiness and psychomotor impairment. Falls and driving accidents are the main concerns.
How serious is the interaction between Lemborexant and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible; if necessary, use the lowest doses and consider reducing lemborexant. Counsel about next-day impairment.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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