Drug interactions
Lemborexant + Paroxetine
Severity: Moderate
Lemborexant and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is metabolized by CYP3A4, and paroxetine may weakly raise its exposure. Both drugs also cause sedation, so next-day drowsiness and impaired psychomotor performance may be increased.
What this interaction means in plain words
Lemborexant and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition plus additive CNS depression.
What to do
Limit the lemborexant dose to the lower maximum recommended with weak CYP3A4 inhibitors. Counsel about next-day somnolence and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Paroxetine?
MediHelp rates the interaction as moderate. Lemborexant and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is metabolized by CYP3A4, and paroxetine may weakly raise its exposure. Both drugs also cause sedation, so next-day drowsiness and impaired psychomotor performance may be increased.
How serious is the interaction between Lemborexant and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lemborexant dose to the lower maximum recommended with weak CYP3A4 inhibitors. Counsel about next-day somnolence and driving.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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