Drug interactions
Lemborexant + Pazopanib
Severity: Moderate
Lemborexant and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib, a weak CYP3A4 inhibitor, may increase lemborexant levels. This can cause excess somnolence and next-day impairment.
What this interaction means in plain words
Lemborexant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition reduces lemborexant clearance.
What to do
Limit lemborexant to the reduced maximum nightly dose recommended with weak CYP3A4 inhibitors. Monitor for daytime sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Pazopanib?
MediHelp rates the interaction as moderate. Lemborexant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib, a weak CYP3A4 inhibitor, may increase lemborexant levels. This can cause excess somnolence and next-day impairment.
How serious is the interaction between Lemborexant and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum nightly dose recommended with weak CYP3A4 inhibitors. Monitor for daytime sedation.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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