Drug interactions
Lemborexant + Phenelzine
Severity: Moderate
Lemborexant and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a sedating orexin receptor antagonist and phenelzine can also cause drowsiness. Together they may increase next-day somnolence and impair psychomotor performance, including driving.
What this interaction means in plain words
Lemborexant and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective lemborexant dose and monitor for daytime sedation. Advise patients to avoid driving or hazardous tasks if impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Phenelzine?
MediHelp rates the interaction as moderate. Lemborexant and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant is a sedating orexin receptor antagonist and phenelzine can also cause drowsiness. Together they may increase next-day somnolence and impair psychomotor performance, including driving.
How serious is the interaction between Lemborexant and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and monitor for daytime sedation. Advise patients to avoid driving or hazardous tasks if impaired.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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