Drug interactions
Lemborexant + Quinine
Severity: Moderate
Lemborexant and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is a weak CYP3A4 inhibitor and can increase lemborexant exposure. This may increase next-day somnolence and impaired alertness.
What this interaction means in plain words
Lemborexant and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lemborexant by quinine.
What to do
Limit the lemborexant dose to the lower dose recommended in labeling with weak CYP3A4 inhibitors. Counsel patients about next-day drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Quinine?
MediHelp rates the interaction as moderate. Lemborexant and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine is a weak CYP3A4 inhibitor and can increase lemborexant exposure. This may increase next-day somnolence and impaired alertness.
How serious is the interaction between Lemborexant and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lemborexant dose to the lower dose recommended in labeling with weak CYP3A4 inhibitors. Counsel patients about next-day drowsiness and driving.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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