Drug interactions
Lemborexant + Selegiline
Severity: Moderate
Lemborexant and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline may raise lemborexant levels through weak CYP3A4 inhibition, increasing sedation. Lemborexant may also modestly lower selegiline exposure, and the clinical effect of that is uncertain.
What this interaction means in plain words
Lemborexant and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lemborexant belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by selegiline and possible CYP2B6 induction by lemborexant.
What to do
Use the lower nightly lemborexant dose recommended with weak CYP3A4 inhibitors. Monitor selegiline response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Lemborexant with Selegiline?
MediHelp rates the interaction as moderate. Lemborexant and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline may raise lemborexant levels through weak CYP3A4 inhibition, increasing sedation. Lemborexant may also modestly lower selegiline exposure, and the clinical effect of that is uncertain.
How serious is the interaction between Lemborexant and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lower nightly lemborexant dose recommended with weak CYP3A4 inhibitors. Monitor selegiline response.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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