Drug interactions
Lenacapavir + Levonorgestrel
Severity: Minor
Lenacapavir and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise levonorgestrel concentrations. The clinical consequence is likely small because levonorgestrel has a wide margin of safety, but progestogenic adverse effects could increase.
What this interaction means in plain words
Lenacapavir and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenacapavir belongs to Anti Virals; Levonorgestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 by lenacapavir reduces the metabolism of levonorgestrel.
What to do
No routine dose change is needed; monitor for progestogenic adverse effects such as bleeding changes, headache or mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Levonorgestrel?
MediHelp rates the interaction as minor. Lenacapavir and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A inhibitor and may raise levonorgestrel concentrations. The clinical consequence is likely small because levonorgestrel has a wide margin of safety, but progestogenic adverse effects could increase.
How serious is the interaction between Lenacapavir and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for progestogenic adverse effects such as bleeding changes, headache or mood changes.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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