Drug interactions
Lenacapavir + Pimavanserin
Severity: Moderate
Lenacapavir and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir inhibits CYP3A4 and may increase pimavanserin concentrations. This could raise the risk of adverse effects such as QT prolongation, and the inhibitory effect may persist for months after the last injection.
What this interaction means in plain words
Lenacapavir and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Pimavanserin belongs to Central Nervous System.
Why it happens
Moderate CYP3A4 inhibition by lenacapavir reduces pimavanserin clearance.
What to do
Monitor for pimavanserin adverse effects and consider an ECG in patients with QT risk factors. Consider a pimavanserin dose reduction if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Pimavanserin?
MediHelp rates the interaction as moderate. Lenacapavir and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir inhibits CYP3A4 and may increase pimavanserin concentrations. This could raise the risk of adverse effects such as QT prolongation, and the inhibitory effect may persist for months after the last injection.
How serious is the interaction between Lenacapavir and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pimavanserin adverse effects and consider an ECG in patients with QT risk factors. Consider a pimavanserin dose reduction if adverse effects occur.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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