Drug interactions
Lenacapavir + Praziquantel
Severity: Moderate
Lenacapavir and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may modestly increase praziquantel exposure. This could add to dose-related adverse effects such as dizziness and somnolence.
What this interaction means in plain words
Lenacapavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Praziquantel belongs to Anti Parasitic.
Why it happens
Lenacapavir inhibits CYP3A4, reducing praziquantel clearance.
What to do
Monitor for increased praziquantel adverse effects and counsel the patient about dizziness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Praziquantel?
MediHelp rates the interaction as moderate. Lenacapavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may modestly increase praziquantel exposure. This could add to dose-related adverse effects such as dizziness and somnolence.
How serious is the interaction between Lenacapavir and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased praziquantel adverse effects and counsel the patient about dizziness and driving.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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