Drug interactions
Lenacapavir + Quinine
Severity: Moderate
Lenacapavir and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir inhibits CYP3A4 moderately and its long-acting subcutaneous formulation persists for months. Quinine is a CYP3A4 substrate with a narrow therapeutic window, so its levels may rise. This could provoke cinchonism or QT prolongation.
What this interaction means in plain words
Lenacapavir and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Quinine belongs to Anti Parasitic.
Why it happens
Lenacapavir inhibits CYP3A4, reducing the metabolism of quinine.
What to do
Monitor for quinine adverse effects and consider an ECG if the course is longer than a few days. Dose reduce quinine if toxicity signs develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Quinine?
MediHelp rates the interaction as moderate. Lenacapavir and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir inhibits CYP3A4 moderately and its long-acting subcutaneous formulation persists for months. Quinine is a CYP3A4 substrate with a narrow therapeutic window, so its levels may rise. This could provoke cinchonism or QT prolongation.
How serious is the interaction between Lenacapavir and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine adverse effects and consider an ECG if the course is longer than a few days. Dose reduce quinine if toxicity signs develop.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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