Drug interactions
Lenacapavir + Sorafenib
Severity: Moderate
Lenacapavir and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, with the effect persisting for months after subcutaneous dosing. Sorafenib exposure may increase modestly, although other pathways such as UGT1A9 contribute to its clearance.
What this interaction means in plain words
Lenacapavir and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Lenacapavir inhibits CYP3A4, reducing sorafenib metabolism.
What to do
Monitor for sorafenib toxicity, including skin reactions, hypertension and diarrhea, and reduce the dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Sorafenib?
MediHelp rates the interaction as moderate. Lenacapavir and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, with the effect persisting for months after subcutaneous dosing. Sorafenib exposure may increase modestly, although other pathways such as UGT1A9 contribute to its clearance.
How serious is the interaction between Lenacapavir and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib toxicity, including skin reactions, hypertension and diarrhea, and reduce the dose if adverse effects emerge.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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