Drug interactions
Lenacapavir + Tolterodine
Severity: Moderate
Lenacapavir and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may raise tolterodine exposure, with the effect lasting for months after subcutaneous dosing. Higher levels increase anticholinergic effects.
What this interaction means in plain words
Lenacapavir and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Tolterodine belongs to Genitourinary.
Why it happens
Moderate CYP3A4 inhibition by lenacapavir reduces tolterodine clearance.
What to do
Monitor for anticholinergic adverse effects and consider reducing tolterodine dose, particularly in CYP2D6 poor metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Tolterodine?
MediHelp rates the interaction as moderate. Lenacapavir and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may raise tolterodine exposure, with the effect lasting for months after subcutaneous dosing. Higher levels increase anticholinergic effects.
How serious is the interaction between Lenacapavir and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and consider reducing tolterodine dose, particularly in CYP2D6 poor metabolizers.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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