Drug interactions
Lenacapavir + Vincristine
Severity: Moderate
Lenacapavir and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and its effect persists for months after a subcutaneous dose. This may raise vincristine concentrations and increase neurotoxicity and gastrointestinal toxicity.
What this interaction means in plain words
Lenacapavir and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Vincristine belongs to Oncology.
Why it happens
Lenacapavir inhibits CYP3A4, reducing vincristine metabolism.
What to do
Monitor closely for neuropathy, constipation and ileus. Consider a vincristine dose reduction and keep in mind that lenacapavir inhibition persists long after the last injection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Vincristine?
MediHelp rates the interaction as moderate. Lenacapavir and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and its effect persists for months after a subcutaneous dose. This may raise vincristine concentrations and increase neurotoxicity and gastrointestinal toxicity.
How serious is the interaction between Lenacapavir and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neuropathy, constipation and ileus. Consider a vincristine dose reduction and keep in mind that lenacapavir inhibition persists long after the last injection.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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