Drug interactions
Lenacapavir + Vinorelbine
Severity: Moderate
Lenacapavir and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir moderately inhibits CYP3A and its effect persists for months after subcutaneous dosing. Vinorelbine exposure may rise and increase toxicity.
What this interaction means in plain words
Lenacapavir and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenacapavir belongs to Anti Virals; Vinorelbine belongs to Oncology.
Why it happens
Lenacapavir inhibits CYP3A4, reducing vinorelbine metabolism.
What to do
Monitor blood counts and neurotoxicity, including for months after the last lenacapavir injection. Reduce the vinorelbine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Lenacapavir with Vinorelbine?
MediHelp rates the interaction as moderate. Lenacapavir and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir moderately inhibits CYP3A and its effect persists for months after subcutaneous dosing. Vinorelbine exposure may rise and increase toxicity.
How serious is the interaction between Lenacapavir and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity, including for months after the last lenacapavir injection. Reduce the vinorelbine dose if toxicity develops.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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