Drug interactions
Lenalidomide + Palifermin
Severity: Moderate
Lenalidomide and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin is used to reduce mucositis after myelotoxic chemotherapy, and labeling advises against giving it close to cytotoxic chemotherapy because it may worsen mucositis. Lenalidomide is oral and not typically given in this setting, so the relevance is uncertain.
What this interaction means in plain words
Lenalidomide and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenalidomide belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin stimulates epithelial cell proliferation, which may increase susceptibility of dividing mucosal cells to cytotoxic drugs.
What to do
Avoid giving palifermin within 24 hours before, during, or after cytotoxic therapy; reassess need for palifermin if lenalidomide is being used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Other interactions of Palifermin
Frequently asked questions
Can I take Lenalidomide with Palifermin?
MediHelp rates the interaction as moderate. Lenalidomide and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin is used to reduce mucositis after myelotoxic chemotherapy, and labeling advises against giving it close to cytotoxic chemotherapy because it may worsen mucositis. Lenalidomide is oral and not typically given in this setting, so the relevance is uncertain.
How serious is the interaction between Lenalidomide and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving palifermin within 24 hours before, during, or after cytotoxic therapy; reassess need for palifermin if lenalidomide is being used.
What other medicines interact with Lenalidomide?
MediHelp also lists interactions of Lenalidomide with, for example, Deferiprone, Ropeginterferon alfa 2b, Acalabrutinib. The full list is on the Lenalidomide page.
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