Drug interactions
Lenalidomide + Trastuzumab
Severity: Minor
Lenalidomide and Trastuzumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab can worsen neutropenia when given with myelosuppressive agents, and lenalidomide frequently causes neutropenia. Combined use may therefore raise the risk of infection.
What this interaction means in plain words
Lenalidomide and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lenalidomide belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Possible additive neutropenia; no direct pharmacokinetic interaction is established.
What to do
Monitor complete blood counts regularly and adjust lenalidomide dose per labeling if neutropenia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lenalidomide
- Deferiprone + Lenalidomide Major
- Lenalidomide + Ropeginterferon alfa 2b Major
- Acalabrutinib + Lenalidomide Moderate
- Anakinra + Lenalidomide Moderate
- Cholera vaccine + Lenalidomide Moderate
- Denosumab + Lenalidomide Moderate
Other interactions of Trastuzumab
Frequently asked questions
Can I take Lenalidomide with Trastuzumab?
MediHelp rates the interaction as minor. Lenalidomide and Trastuzumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trastuzumab can worsen neutropenia when given with myelosuppressive agents, and lenalidomide frequently causes neutropenia. Combined use may therefore raise the risk of infection.
How serious is the interaction between Lenalidomide and Trastuzumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust lenalidomide dose per labeling if neutropenia develops.
What other medicines interact with Lenalidomide?
MediHelp also lists interactions of Lenalidomide with, for example, Deferiprone, Ropeginterferon alfa 2b, Acalabrutinib. The full list is on the Lenalidomide page.
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