Drug interactions
Leniolisib + Levonorgestrel
Severity: Minor
Leniolisib and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib modestly raises ethinylestradiol exposure in combined contraceptives, but contraceptive efficacy is not expected to be reduced. Any increase in estrogenic adverse effects is likely small.
What this interaction means in plain words
Leniolisib and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leniolisib belongs to Miscellaneous; Levonorgestrel belongs to Endocrine.
Why it happens
Leniolisib likely modestly inhibits metabolism or transport of ethinylestradiol; the exact mechanism is not established.
What to do
No dose change is needed; counsel the patient about estrogen-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Leniolisib
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Leniolisib with Levonorgestrel?
MediHelp rates the interaction as minor. Leniolisib and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib modestly raises ethinylestradiol exposure in combined contraceptives, but contraceptive efficacy is not expected to be reduced. Any increase in estrogenic adverse effects is likely small.
How serious is the interaction between Leniolisib and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; counsel the patient about estrogen-related adverse effects.
What other medicines interact with Leniolisib?
MediHelp also lists interactions of Leniolisib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Leniolisib page.
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