Drug interactions
Leniolisib + Lorlatinib
Severity: Moderate
Leniolisib and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower leniolisib exposure through CYP3A4 induction, which could reduce efficacy in activated PI3K delta syndrome.
What this interaction means in plain words
Leniolisib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Lorlatinib belongs to Oncology.
Why it happens
CYP3A4 induction by lorlatinib increases leniolisib metabolism.
What to do
Monitor clinical response to leniolisib, and avoid the combination if an alternative is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Lorlatinib?
MediHelp rates the interaction as moderate. Leniolisib and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower leniolisib exposure through CYP3A4 induction, which could reduce efficacy in activated PI3K delta syndrome.
How serious is the interaction between Leniolisib and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to leniolisib, and avoid the combination if an alternative is available.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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