Drug interactions
Leniolisib + Measles mumps and rubella vaccine
Severity: Moderate
Leniolisib and Measles mumps and rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a PI3K delta inhibitor that modulates lymphocyte function, so the response to live vaccines may be reduced. In addition, live vaccine viruses could replicate more than intended in a patient with immune impairment.
What this interaction means in plain words
Leniolisib and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Measles mumps and rubella vaccine belongs to Miscellaneous.
Why it happens
PI3K delta inhibition alters B and T cell function, which may impair vaccine responses and permit uncontrolled replication of live attenuated virus.
What to do
Give any needed live vaccines before starting leniolisib where possible, and review labeling and specialist advice before vaccinating during treatment. Monitor for vaccine-related infection and consider checking antibody titers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Measles mumps and rubella vaccine?
MediHelp rates the interaction as moderate. Leniolisib and Measles mumps and rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a PI3K delta inhibitor that modulates lymphocyte function, so the response to live vaccines may be reduced. In addition, live vaccine viruses could replicate more than intended in a patient with immune impairment.
How serious is the interaction between Leniolisib and Measles mumps and rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give any needed live vaccines before starting leniolisib where possible, and review labeling and specialist advice before vaccinating during treatment. Monitor for vaccine-related infection and consider checking antibody titers.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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