Drug interactions
Leniolisib + Metformin-repaglinide
Severity: Moderate
Leniolisib and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3, which may raise repaglinide exposure and the risk of hypoglycemia.
What this interaction means in plain words
Leniolisib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of repaglinide.
What to do
Monitor blood glucose and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Leniolisib and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3, which may raise repaglinide exposure and the risk of hypoglycemia.
How serious is the interaction between Leniolisib and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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