Drug interactions
Leniolisib + Pazopanib
Severity: Moderate
Leniolisib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, and pazopanib is a BCRP substrate, so pazopanib exposure may increase. This could heighten dose-related adverse effects.
What this interaction means in plain words
Leniolisib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux by leniolisib, increasing pazopanib absorption.
What to do
Monitor for pazopanib toxicity, including liver enzymes and blood pressure, and reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Pazopanib?
MediHelp rates the interaction as moderate. Leniolisib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, and pazopanib is a BCRP substrate, so pazopanib exposure may increase. This could heighten dose-related adverse effects.
How serious is the interaction between Leniolisib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pazopanib toxicity, including liver enzymes and blood pressure, and reduce the dose if adverse effects occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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