Drug interactions
Leniolisib + Pirfenidone
Severity: Moderate
Leniolisib and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib is a weak CYP1A2 inhibitor and may modestly increase exposure to sensitive CYP1A2 substrates such as pirfenidone. This could increase gastrointestinal, photosensitivity and hepatic adverse effects.
What this interaction means in plain words
Leniolisib and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Pirfenidone belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2 by leniolisib reduces pirfenidone metabolism.
What to do
Monitor for pirfenidone adverse effects and liver function tests, and lower the pirfenidone dose if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Pirfenidone?
MediHelp rates the interaction as moderate. Leniolisib and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib is a weak CYP1A2 inhibitor and may modestly increase exposure to sensitive CYP1A2 substrates such as pirfenidone. This could increase gastrointestinal, photosensitivity and hepatic adverse effects.
How serious is the interaction between Leniolisib and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone adverse effects and liver function tests, and lower the pirfenidone dose if tolerability worsens.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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