Drug interactions
Leniolisib + Rasagiline
Severity: Moderate
Leniolisib and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits CYP1A2, the main enzyme clearing rasagiline, and may increase rasagiline exposure and adverse effects.
What this interaction means in plain words
Leniolisib and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.
Why it happens
Leniolisib inhibits CYP1A2-mediated rasagiline metabolism.
What to do
If both are needed, reduce the rasagiline dose per labeling and monitor for adverse effects such as hypotension and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Rasagiline?
MediHelp rates the interaction as moderate. Leniolisib and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits CYP1A2, the main enzyme clearing rasagiline, and may increase rasagiline exposure and adverse effects.
How serious is the interaction between Leniolisib and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, reduce the rasagiline dose per labeling and monitor for adverse effects such as hypotension and dizziness.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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