Drug interactions
Leniolisib + Ropinirole
Severity: Moderate
Leniolisib and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib weakly inhibits CYP1A2 and may raise exposure to sensitive CYP1A2 substrates such as ropinirole. This may increase dopaminergic adverse effects including somnolence, orthostatic hypotension and nausea.
What this interaction means in plain words
Leniolisib and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Ropinirole belongs to Central Nervous System.
Why it happens
Leniolisib inhibits CYP1A2, reducing hepatic clearance of ropinirole.
What to do
Monitor for ropinirole adverse effects and lower the ropinirole dose if needed. Adjust to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Ropinirole?
MediHelp rates the interaction as moderate. Leniolisib and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib weakly inhibits CYP1A2 and may raise exposure to sensitive CYP1A2 substrates such as ropinirole. This may increase dopaminergic adverse effects including somnolence, orthostatic hypotension and nausea.
How serious is the interaction between Leniolisib and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ropinirole adverse effects and lower the ropinirole dose if needed. Adjust to clinical response.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
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