Drug interactions
Leniolisib + Sulphasalazine
Severity: Moderate
Leniolisib and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may increase systemic exposure to sulfasalazine, a sensitive BCRP substrate. This could increase sulfasalazine adverse effects such as GI upset, rash and cytopenias.
What this interaction means in plain words
Leniolisib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Leniolisib inhibition of BCRP-mediated sulfasalazine efflux.
What to do
Monitor for sulfasalazine toxicity including blood counts and liver tests. Reduce the sulfasalazine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Sulphasalazine?
MediHelp rates the interaction as moderate. Leniolisib and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP and may increase systemic exposure to sulfasalazine, a sensitive BCRP substrate. This could increase sulfasalazine adverse effects such as GI upset, rash and cytopenias.
How serious is the interaction between Leniolisib and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sulfasalazine toxicity including blood counts and liver tests. Reduce the sulfasalazine dose if adverse effects occur.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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