Drug interactions
Leniolisib + Valsartan
Severity: Moderate
Leniolisib and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits OATP1B1 and OATP1B3 and may increase valsartan exposure. This may lead to enhanced blood pressure lowering.
What this interaction means in plain words
Leniolisib and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leniolisib belongs to Miscellaneous; Valsartan belongs to Cardiovascular.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake of valsartan.
What to do
Monitor blood pressure and renal function and reduce the valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Leniolisib with Valsartan?
MediHelp rates the interaction as moderate. Leniolisib and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits OATP1B1 and OATP1B3 and may increase valsartan exposure. This may lead to enhanced blood pressure lowering.
How serious is the interaction between Leniolisib and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function and reduce the valsartan dose if hypotension occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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