Drug interactions
Lesinurad + Levonorgestrel
Severity: Moderate
Lesinurad and Levonorgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lesinurad is a weak CYP3A inducer and may reduce levonorgestrel concentrations. This may lower the reliability of oral or emergency contraception and risk unintended pregnancy.
What this interaction means in plain words
Lesinurad and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lesinurad belongs to Genitourinary; Levonorgestrel belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 by lesinurad increases levonorgestrel metabolism.
What to do
Recommend a backup nonhormonal contraceptive method during lesinurad therapy. Consider an alternative to levonorgestrel emergency contraception, such as a copper IUD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lesinurad
- Lesinurad + Norethisterone Major
- Acetylsalicylic acid + Lesinurad Moderate
- Amiodarone + Lesinurad Moderate
- Apalutamide + Lesinurad Moderate
- Desogestrel-ethinyl estradiol + Lesinurad Moderate
- Dienogest / estradiol valerate + Lesinurad Moderate
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Lesinurad with Levonorgestrel?
MediHelp rates the interaction as moderate. Lesinurad and Levonorgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lesinurad is a weak CYP3A inducer and may reduce levonorgestrel concentrations. This may lower the reliability of oral or emergency contraception and risk unintended pregnancy.
How serious is the interaction between Lesinurad and Levonorgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend a backup nonhormonal contraceptive method during lesinurad therapy. Consider an alternative to levonorgestrel emergency contraception, such as a copper IUD.
What other medicines interact with Lesinurad?
MediHelp also lists interactions of Lesinurad with, for example, Norethisterone, Acetylsalicylic acid, Amiodarone. The full list is on the Lesinurad page.
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