Drug interactions
Letermovir + Olmesartan
Severity: Moderate
Letermovir and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits hepatic uptake transporters and may increase olmesartan plasma concentrations. Higher exposure may intensify hypotension, hyperkalemia or renal effects.
What this interaction means in plain words
Letermovir and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Olmesartan belongs to Cardiovascular.
Why it happens
Letermovir inhibition of OATP1B1/1B3 reduces hepatic uptake and clearance of olmesartan.
What to do
Monitor blood pressure, potassium and renal function while the two are coadministered. Reduce the olmesartan dose if hypotension or hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Olmesartan?
MediHelp rates the interaction as moderate. Letermovir and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits hepatic uptake transporters and may increase olmesartan plasma concentrations. Higher exposure may intensify hypotension, hyperkalemia or renal effects.
How serious is the interaction between Letermovir and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function while the two are coadministered. Reduce the olmesartan dose if hypotension or hyperkalemia develops.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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