Drug interactions
Letermovir + Propranolol
Severity: Minor
Letermovir and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir may modestly raise propranolol exposure, though propranolol is metabolized by several pathways including CYP2D6, CYP1A2 and CYP2C19. Effects could include bradycardia or hypotension.
What this interaction means in plain words
Letermovir and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Propranolol belongs to Cardiovascular.
Why it happens
Letermovir inhibits CYP3A and may alter other enzymes, slightly reducing propranolol clearance; clinical significance is uncertain.
What to do
Monitor heart rate and blood pressure after letermovir is started and reduce the propranolol dose if bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Propranolol?
MediHelp rates the interaction as minor. Letermovir and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir may modestly raise propranolol exposure, though propranolol is metabolized by several pathways including CYP2D6, CYP1A2 and CYP2C19. Effects could include bradycardia or hypotension.
How serious is the interaction between Letermovir and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after letermovir is started and reduce the propranolol dose if bradycardia occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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