Drug interactions
Letermovir + Rabeprazole
Severity: Minor
Letermovir and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 but also induces CYP2C19 and CYP2C9, so its effect on PPIs is mixed. Rabeprazole is mainly cleared non-enzymatically, so large changes in exposure are not expected.
What this interaction means in plain words
Letermovir and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Letermovir modulates CYP3A4 and CYP2C19, minor routes for rabeprazole.
What to do
No empiric dose change is needed. Monitor for reduced acid suppression or PPI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Rabeprazole?
MediHelp rates the interaction as minor. Letermovir and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits CYP3A4 but also induces CYP2C19 and CYP2C9, so its effect on PPIs is mixed. Rabeprazole is mainly cleared non-enzymatically, so large changes in exposure are not expected.
How serious is the interaction between Letermovir and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for reduced acid suppression or PPI adverse effects.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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