Drug interactions
Letermovir + Rifaximin
Severity: Minor
Letermovir and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits several transporters and CYP3A, and rifaximin exposure may rise slightly. Because rifaximin is minimally absorbed, clinical significance is expected to be low.
What this interaction means in plain words
Letermovir and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Rifaximin belongs to Anti Bacterial.
Why it happens
Possible transporter (P-gp/OATP) inhibition increasing rifaximin absorption; CYP3A contribution is minor.
What to do
No routine adjustment is needed. Watch for rifaximin adverse effects in patients with severe hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Rifaximin?
MediHelp rates the interaction as minor. Letermovir and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits several transporters and CYP3A, and rifaximin exposure may rise slightly. Because rifaximin is minimally absorbed, clinical significance is expected to be low.
How serious is the interaction between Letermovir and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for rifaximin adverse effects in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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