Drug interactions
Letermovir + Telmisartan-amlodipine
Severity: Minor
Letermovir and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/3 and may increase telmisartan exposure. Letermovir levels are not expected to change meaningfully with telmisartan. Higher telmisartan levels could add to hypotension, hyperkalemia or renal effects.
What this interaction means in plain words
Letermovir and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Letermovir inhibition of OATP1B1/3 can increase plasma concentrations of telmisartan.
What to do
Monitor blood pressure and potassium during letermovir therapy. Reduce the telmisartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Letermovir and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir inhibits OATP1B1/3 and may increase telmisartan exposure. Letermovir levels are not expected to change meaningfully with telmisartan. Higher telmisartan levels could add to hypotension, hyperkalemia or renal effects.
How serious is the interaction between Letermovir and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and potassium during letermovir therapy. Reduce the telmisartan dose if hypotension occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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