Drug interactions
Letermovir + Telmisartan
Severity: Moderate
Letermovir and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/3 and may raise telmisartan concentrations, with possible increased ARB effects such as hypotension or hyperkalemia. Telmisartan is unlikely to change letermovir exposure to a meaningful degree.
What this interaction means in plain words
Letermovir and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Telmisartan belongs to Cardiovascular.
Why it happens
Letermovir inhibition of hepatic OATP1B1/3 uptake raises exposure of telmisartan.
What to do
Monitor blood pressure, renal function and potassium during letermovir therapy. Reduce the telmisartan dose if hypotension or adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Letermovir and Telmisartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Telmisartan?
MediHelp rates the interaction as moderate. Letermovir and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits OATP1B1/3 and may raise telmisartan concentrations, with possible increased ARB effects such as hypotension or hyperkalemia. Telmisartan is unlikely to change letermovir exposure to a meaningful degree.
How serious is the interaction between Letermovir and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium during letermovir therapy. Reduce the telmisartan dose if hypotension or adverse effects appear.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
