Drug interactions
Letermovir + Tenofovir disoproxil
Severity: Minor
Letermovir and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is not a P-gp inducer, so it is not expected to reduce letermovir exposure. The legacy claim is not supported by the mechanism.
What this interaction means in plain words
Letermovir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; tenofovir does not induce P-gp.
What to do
No dose adjustment is needed; monitor renal function as usual with tenofovir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Letermovir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir is not a P-gp inducer, so it is not expected to reduce letermovir exposure. The legacy claim is not supported by the mechanism.
How serious is the interaction between Letermovir and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor renal function as usual with tenofovir.
What other medicines interact with Letermovir?
MediHelp also lists interactions of Letermovir with, for example, Ergotamine, Pimozide, Apalutamide. The full list is on the Letermovir page.
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