Drug interactions
Letermovir + Zaleplon
Severity: Minor
Letermovir and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor, which may modestly raise zaleplon concentrations. Because CYP3A4 is a minor route for zaleplon, the effect is likely small but may increase sedation.
What this interaction means in plain words
Letermovir and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Letermovir belongs to Anti Virals; Zaleplon belongs to Central Nervous System.
Why it happens
Letermovir inhibition of CYP3A4 slightly reduces zaleplon metabolism.
What to do
No routine dose change is needed. Monitor for increased drowsiness and lower the zaleplon dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Zaleplon?
MediHelp rates the interaction as minor. Letermovir and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir is a moderate CYP3A inhibitor, which may modestly raise zaleplon concentrations. Because CYP3A4 is a minor route for zaleplon, the effect is likely small but may increase sedation.
How serious is the interaction between Letermovir and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased drowsiness and lower the zaleplon dose if it occurs.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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