Drug interactions
Letermovir + Zolpidem
Severity: Moderate
Letermovir and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 and can raise levels of CYP3A substrates such as zolpidem. This may increase sedation and next-day impairment. The effect is expected to be modest but clinically relevant in vulnerable patients.
What this interaction means in plain words
Letermovir and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Letermovir belongs to Anti Virals; Zolpidem belongs to Central Nervous System.
Why it happens
Letermovir inhibits CYP3A4 metabolism of zolpidem.
What to do
Start zolpidem at the lowest dose and monitor for oversedation, especially in elderly patients. Reduce the dose if daytime drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Letermovir with Zolpidem?
MediHelp rates the interaction as moderate. Letermovir and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 and can raise levels of CYP3A substrates such as zolpidem. This may increase sedation and next-day impairment. The effect is expected to be modest but clinically relevant in vulnerable patients.
How serious is the interaction between Letermovir and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start zolpidem at the lowest dose and monitor for oversedation, especially in elderly patients. Reduce the dose if daytime drowsiness occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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