Drug interactions
Levalbuterol + Mefenamic acid
Severity: Minor
Levalbuterol and Mefenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levalbuterol can lower serum potassium by shifting it into cells, whereas NSAIDs can reduce renal potassium excretion. The net effect is unpredictable and usually small, with hypokalemia from beta-agonist use being the main concern at high doses.
What this interaction means in plain words
Levalbuterol and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on potassium: beta-2 stimulation drives intracellular uptake while NSAIDs reduce renal potassium excretion via suppressed prostaglandins and renin.
What to do
No routine action; check potassium if high-dose or repeated levalbuterol is used with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Levalbuterol with Mefenamic acid?
MediHelp rates the interaction as minor. Levalbuterol and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levalbuterol can lower serum potassium by shifting it into cells, whereas NSAIDs can reduce renal potassium excretion. The net effect is unpredictable and usually small, with hypokalemia from beta-agonist use being the main concern at high doses.
How serious is the interaction between Levalbuterol and Mefenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; check potassium if high-dose or repeated levalbuterol is used with renal impairment.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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